Semiconductors for SERS
The ability to probe biological processes at a cellular level is critical to the examination of disease pathogenesis, diagnosis, and treatment.
Devices for Exosome-Based Sensing
To develop ultrasensitive screening devices for multifactorial diseases like Alzheimer’s, we are working on developing microfluidic devices incorporating surface-enhanced Raman spectroscopy (SERS). SERS is an optical biosensing technique with unmatched spatial and temporal detection capabilities, endowing it with significant potential for highly sensitive detection of extracellular vesicle-derived constituents.
Engineering Exosomes for Advanced Functionalities
The multifaceted nature of exosomes (i.e., size, diverse macromolecular constituents, and a composition that reflects their cell of origin) means that exosomes have enormous potential for multiplexed detection and high throughput analysis to benefit a variety of biological applications, as well as therapeutic applications and delivery. Our lab is investigating there application in strategies to combat Parkinson’s disease, Alzheimer’s disease, and cancer.